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KMID : 1138520190220030171
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Journal of Pharmacopuncture
2019 Volume.22 No. 3 p.171 ~ p.175
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Evaluation of the Single-Dose Toxicity of TA Pharmacopuncture in Rat
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Hwang Ji-Hye
Jung Hyo-Won
Jung Chul
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Abstract
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Objectives: TA is a polyherbal extract comprising seven herbs, typically used for the pharmacopuncture treatment of patients with traffic accident- related injuries and musculoskeletal diseases. This animal study was conducted to evaluate the safety of the TA extract, using a single-dose toxicity test.
Methods: The dose range and sampling time were first established. Six- week-old Sprague?Dawley rats were administered 1.0 mL of TA or normal saline (control), intramuscularly, for the single-dose toxicity test. The general condition, mortality, and histology of all rats were observed for 2 weeks.
Results: No abnormal symptoms or deaths were observed in any group. The body weights of the rats in the TA and control groups were similar. No significant differenc-es in histopathology were observed between the groups.
Conclusion : Our study indicates that 1.0 mL of TA extract may be safely administered for pharmacopuncture for treatment of patients in traditional medicine clinics.
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KEYWORD
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safety, single-dose intramuscular toxicity, TA pharmacopuncture, traditional medicine, acupuncture
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